A 45-year-old man with intractable ulcerative colitis (UC) presents with a 6-month history of frequent bloody, loose bowel movements up to 15 times daily. He has significant urgency and anemia with a hemoglobin of 6.8 g/dL. He has had a 30-lb weight loss in the past 6 months, and his albumin level is 2.5 g/dL. He has been on infliximab and adalimumab in the past and is currently on vedolizumab and 40 mg/day of prednisone. What is the best next step in this patient’s management?